Silane Modification of Mesoporous Materials for the Optimization of Antiviral Drug Adsorption and Release Capabilities in Vaginal Media

Three different functionalities have been incorporated into mesoporous materials by means of a coupling reaction with the siloxanes 3-glycidoxypropyl-trimethoxysilane (GLYMO), 3-methacryloxypropyl-trimethoxysilane (MEMO), and 3-mercaptopropyl-trimethoxysilane (MPTMS). The disposition functional groups, as well interaction mechanism, substrate has identified. amount antiviral drug acyclovir (ACV) adsorbed depends not only on available surface area but also chemical or physicochemical interactions between functionalities. adsorption isotherm functionalized GLYMO MPTMS follow mechanisms dependent coverage possibilities to establish molecule On contrary, when functionalizing MEMO, dominant mechanism is characteristic chemically bonded adsorbates. ACV release kinetics best fitted Weibull model in all materials. When MTPMS used agent, diffusion occurs at low homogeneously along channels.